caspase 4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP1466	Z-YVAD-FMK		Caspase
	AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.		Caspase
T27242	EF24	EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone	ERK , MEK , Caspase
	EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral ...		ERK , MEK , Caspase
T8296	5,7,4'-Trimethoxyflavone	4',5,7-Trimethoxyflavone	Apoptosis , PARP , Caspase
	5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.		Apoptosis , PARP , Caspase
T5S1805	5,7-Dihydroxychromone	5,7-Dihydroxy-4H-Chromen-4-One	Others , Virus Protease , PARP , Caspase , Nrf2
	1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai...		Others , Virus Protease , PARP , Caspase , Nrf2
T18909	Ac-DEVD-AMC	AC-ASP-MET-GLN-ASP-AMC,AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN	Caspase
	Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .		Caspase
T12412L	PDK4-IN-1 hydrochloride		Apoptosis , PDK
	PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM)		Apoptosis , PDK
T36819	Ac-FLTD-CMK		Caspase
	Ac-FLTD-CMK is an inhibitor derived from abscisicin D (GSDMDD) with specific inhibitory effects on inflammatory caspases. ac-FLTD-CMK showed inhibitory effects on caspases-1, caspases-4 and caspases-11 with IC50s of 46.7...		Caspase
T77579	JC2-11		IL Receptor , Dehydrogenase , ROS , Caspase , NOD-like Receptor (NLR) , AIM2
	JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen sp...
T2S2362	Dehydrocorydaline nitrate		BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
T16977	Talampanel	GYKI-53773,LY-300164	Apoptosis , GluR
	Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models.		Apoptosis , GluR
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T6090	Belnacasan	VX-765	Caspase
	Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.		Caspase
T0432	Diclofenac diethylamine		Apoptosis , COX
	Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).		Apoptosis , COX
T4S0498	Glaucocalyxin A	Wangzaozin B,Leukamenin F	Apoptosis , Akt , Caspase , PI3K
	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi...		Apoptosis , Akt , Caspase , PI3K
T1555	Diclofenac sodium	GP 45840	Apoptosis , COX
	Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.		Apoptosis , COX
T4S2126	Ginkgetin		Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy
	1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 ...		Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T1266	Terfenadine	(±)-Terfenadine,MDL-991	Apoptosis , Potassium Channel , 5-HT Receptor , Caspase , Na+/Ca2+ Exchanger , HER , AChR , Histamine Receptor
	Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects.
T6470	Diclofenac Potassium	CGP-45840B,Cataflam,Voltfast	Apoptosis , Others , COX
	Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.		Apoptosis , Others , COX
T0196	Diclofenac	Diclofenacum,Voltaren	Apoptosis , COX
	Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of a...		Apoptosis , COX